| 9/6/2015 | Ark Pine Bluff (2-9) | 7 | vs | South Carolina State | 35 | Orlando FL | SWAC | |
| 9/12/2015 | Coastal Carolina (9-3) | 41 | at | South Carolina State | 14 | BigS | ||
| 9/17/2015 | Florida A&M (1-10,1-7) | 0 | at | South Carolina State | 36 | |||
| 10/3/2015 | South Carolina State | 3 | at | Furman (4-7) | 17 | at SoCon | ||
| 10/8/2015 | South Carolina State | 14 | at | Bethune-Cookman (9-2,7-1) | 17 | |||
| 10/17/2015 | Howard (1-11,1-8) | 10 | at | South Carolina State | 49 | |||
| 10/24/2015 | South Carolina State | 34 | at | Delaware State (1-10,1-7) | 7 | |||
| 10/31/2015 | Hampton (6-5,5-3) | 20 | at | South Carolina State | 34 | |||
| 11/7/2015 | North Carolina A&T (10-2,7-1) | 9 | at | South Carolina State | 6 | |||
| 11/14/2015 | South Carolina State | 17 | at | Norfolk State (4-7,4-4) | 10 | |||
| 11/21/2015 | South Carolina State | 52 | at | Savannah State (1-9,1-7) | 29 |
| vs South Carolina State | vs Other Opponents | South Carolina State compared to OOs | |
| Record: | 4-7 | 44-68 | |
| Points Scored: | 15.18 | 22.30 | 7.12 |
| Points Allowed: | 26.73 | 29.88 | -3.15 |
| Margin: | -11.55 | -7.58 | 3.97 |
| Total Points: | 41.91 | 52.18 | -10.27 |