| 9/5/2015 | Mississippi State | 34 | at | Southern Miss (9-5) | 16 | at CUSA | ||
| 9/12/2015 | LSU (9-3,5-3) | 21 | at | Mississippi State | 19 | |||
| 9/19/2015 | Northwestern State (4-7) | 13 | at | Mississippi State | 62 | SLC (1AA) | ||
| 9/26/2015 | Mississippi State | 17 | at | Auburn (7-6,2-6) | 9 | |||
| 10/3/2015 | Mississippi State | 17 | at | Texas A&M (8-5,4-4) | 30 | |||
| 10/10/2015 | Troy (4-8) | 17 | at | Mississippi State | 45 | SBC | ||
| 10/17/2015 | Louisiana Tech (9-4) | 20 | at | Mississippi State | 45 | CUSA | ||
| 10/24/2015 | Kentucky (5-7,2-6) | 16 | at | Mississippi State | 42 | |||
| 11/5/2015 | Mississippi State | 31 | at | Missouri (5-7,1-7) | 13 | |||
| 11/14/2015 | Alabama (14-1,8-1) | 31 | at | Mississippi State | 6 | |||
| 11/21/2015 | Mississippi State | 51 | at | Arkansas (8-5,5-3) | 50 | |||
| 11/28/2015 | Mississippi (10-3,6-2) | 38 | at | Mississippi State | 27 | |||
| 12/30/2015 | North Carolina State (7-6) | 28 | vs | Mississippi State | 51 | Belk Bowl (Charlotte NC) | ACC |
| vs Mississippi State | vs Other Opponents | Mississippi State compared to OOs | |
| Record: | 4-9 | 95-58 | |
| Points Scored: | 23.23 | 32.11 | 8.88 |
| Points Allowed: | 34.38 | 24.09 | 10.29 |
| Margin: | -11.15 | 8.02 | 19.17 |
| Total Points: | 57.61 | 56.20 | 1.41 |