| 9/5/2015 | Louisville | 24 | vs | Auburn (7-6) | 31 | Atlanta GA | vs SEC | |
| 9/12/2015 | Houston (13-1) | 34 | at | Louisville | 31 | AAC | ||
| 9/17/2015 | Clemson (14-1,9-0) | 20 | at | Louisville | 17 | |||
| 9/26/2015 | Samford (6-5) | 3 | at | Louisville | 45 | SoCon (1AA) | ||
| 10/3/2015 | Louisville | 20 | at | North Carolina State (7-6,3-5) | 13 | |||
| 10/17/2015 | Louisville | 21 | at | Florida State (10-3,6-2) | 41 | |||
| 10/24/2015 | Boston College (3-9,0-8) | 14 | at | Louisville | 17 | |||
| 10/30/2015 | Louisville | 20 | at | Wake Forest (3-9,1-7) | 19 | |||
| 11/7/2015 | Syracuse (4-8,2-6) | 17 | at | Louisville | 41 | |||
| 11/14/2015 | Virginia (4-8,3-5) | 31 | at | Louisville | 38 | |||
| 11/21/2015 | Louisville | 34 | at | Pittsburgh (8-5,6-2) | 45 | |||
| 11/28/2015 | Louisville | 38 | at | Kentucky (5-7) | 24 | at SEC | ||
| 12/30/2015 | Texas A&M (8-5) | 21 | vs | Louisville | 27 | Music City Bowl (Nashville TN) | SEC |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 5-8 | 87-65 | |
| Points Scored: | 24.08 | 29.52 | 5.44 |
| Points Allowed: | 28.69 | 23.86 | 4.83 |
| Margin: | -4.61 | 5.66 | 10.27 |
| Total Points: | 52.77 | 53.38 | -0.61 |