| 9/1/2012 | Waynesburg (10-1) | 34 | at | Muskingum | 23 | TPAC | ||
| 9/15/2012 | Muskingum | 0 | at | Mount Union (15-0,9-0) | 57 | |||
| 9/22/2012 | Baldwin-Wallace (7-3,6-3) | 13 | at | Muskingum | 6 | OT | ||
| 9/29/2012 | Wilmington (1-9,1-8) | 0 | at | Muskingum | 45 | |||
| 10/6/2012 | Muskingum | 13 | at | Otterbein (8-2,7-2) | 23 | |||
| 10/13/2012 | John Carroll (6-4,5-4) | 55 | at | Muskingum | 28 | |||
| 10/20/2012 | Muskingum | 14 | at | Heidelberg (9-2,8-1) | 28 | |||
| 10/27/2012 | Muskingum | 19 | at | Ohio Northern (4-6,4-5) | 20 | |||
| 11/3/2012 | Capital (2-8,2-7) | 6 | at | Muskingum | 13 | OT | ||
| 11/10/2012 | Muskingum | 38 | at | Marietta (0-10,0-9) | 14 |
| vs Muskingum | vs Other Opponents | Muskingum compared to OOs | |
| Record: | 7-3 | 55-42 | |
| Points Scored: | 25.00 | 27.89 | 2.89 |
| Points Allowed: | 19.90 | 24.32 | -4.42 |
| Margin: | 5.10 | 3.57 | -1.53 |
| Total Points: | 44.90 | 52.21 | -7.31 |