| 8/30/2012 | Massachusetts | 0 | at | Connecticut (5-7) | 27 | at BigE | ||
| 9/8/2012 | Indiana (4-8) | 45 | at | Massachusetts | 6 | B10 | ||
| 9/15/2012 | Massachusetts | 13 | at | Michigan (8-5) | 63 | at B10 | ||
| 9/22/2012 | Massachusetts | 16 | at | Miami-Ohio (4-8,3-5) | 27 | |||
| 9/29/2012 | Ohio (9-4,4-4) | 37 | at | Massachusetts | 34 | |||
| 10/6/2012 | Massachusetts | 14 | at | Western Michigan (4-8,2-6) | 52 | |||
| 10/20/2012 | Bowling Green (8-5,6-2) | 24 | at | Massachusetts | 0 | |||
| 10/27/2012 | Massachusetts | 7 | at | Vanderbilt (9-4) | 49 | at SEC | ||
| 11/3/2012 | Massachusetts | 0 | at | Northern Illinois (12-2,9-0) | 63 | |||
| 11/10/2012 | Massachusetts | 22 | at | Akron (1-11,0-8) | 14 | |||
| 11/17/2012 | Buffalo (4-8,3-5) | 29 | at | Massachusetts | 19 | |||
| 11/23/2012 | Central Michigan (7-6,4-4) | 42 | at | Massachusetts | 21 |
| vs Massachusetts | vs Other Opponents | Massachusetts compared to OOs | |
| Record: | 11-1 | 64-75 | |
| Points Scored: | 39.33 | 26.64 | -12.69 |
| Points Allowed: | 12.67 | 27.30 | -14.63 |
| Margin: | 26.66 | -0.66 | -27.32 |
| Total Points: | 52.00 | 53.94 | -1.94 |