| 9/1/2012 | Dayton (6-5) | 14 | at | Illinois State | 56 | Pio | ||
| 9/8/2012 | Illinois State | 31 | at | Eastern Michigan (2-10) | 14 | at MAC | ||
| 9/15/2012 | Eastern Illinois (7-5) | 51 | at | Illinois State | 54 | OVC | ||
| 9/22/2012 | Illinois State | 23 | at | Western Illinois (3-8,1-7) | 3 | |||
| 9/29/2012 | Illinois State | 34 | at | South Dakota (1-10,0-8) | 31 | |||
| 10/6/2012 | Southern Illinois (6-5,5-3) | 17 | at | Illinois State | 0 | |||
| 10/13/2012 | Youngstown State (7-4,4-4) | 28 | at | Illinois State | 35 | |||
| 10/20/2012 | Missouri State (3-8,3-5) | 24 | at | Illinois State | 17 | |||
| 10/27/2012 | Illinois State | 33 | at | Northern Iowa (5-6,4-4) | 21 | |||
| 11/3/2012 | Illinois State | 17 | at | Indiana State (7-4,5-3) | 10 | |||
| 11/17/2012 | North Dakota State (14-1,8-1) | 38 | at | Illinois State | 20 | |||
| 12/1/2012 | Illinois State | 38 | at | Appalachian State (8-4) | 37 | OT | FCS Round 2 | at SoCon |
| 12/8/2012 | Illinois State | 35 | at | Eastern Washington (11-3) | 51 | FCS Quarterfinals | at BSky |
| vs Illinois State | vs Other Opponents | Illinois State compared to OOs | |
| Record: | 4-9 | 76-64 | |
| Points Scored: | 26.08 | 25.76 | -0.32 |
| Points Allowed: | 30.23 | 24.33 | 5.90 |
| Margin: | -4.15 | 1.43 | 5.58 |
| Total Points: | 56.31 | 50.09 | 6.22 |