| 9/1/2012 | Duquesne | 23 | at | Old Dominion (10-3) | 57 | at CAAF | ||
| 9/8/2012 | Dayton (6-5) | 7 | at | Duquesne | 17 | Pio | ||
| 9/15/2012 | Duquesne | 45 | at | Valparaiso (1-10) | 17 | at Pio | ||
| 9/22/2012 | Duquesne | 35 | at | Bryant (4-7,4-4) | 21 | |||
| 9/29/2012 | St Francis PA (5-6,4-4) | 21 | at | Duquesne | 24 | |||
| 10/13/2012 | Duquesne | 31 | at | Central Conn (2-8,2-5) | 38 | |||
| 10/20/2012 | Sacred Heart (2-9,1-7) | 3 | at | Duquesne | 35 | |||
| 10/27/2012 | Monmouth NJ (5-5,4-3) | 28 | at | Duquesne | 27 | |||
| 11/3/2012 | Duquesne | 13 | at | Robert Morris (4-7,3-5) | 17 | |||
| 11/10/2012 | Albany NY (9-2,7-1) | 38 | at | Duquesne | 31 | |||
| 11/17/2012 | Duquesne | 17 | at | Wagner (9-4,7-1) | 23 |
| vs Duquesne | vs Other Opponents | Duquesne compared to OOs | |
| Record: | 6-5 | 51-61 | |
| Points Scored: | 24.55 | 25.99 | 1.44 |
| Points Allowed: | 27.09 | 28.88 | -1.79 |
| Margin: | -2.54 | -2.89 | -0.35 |
| Total Points: | 51.64 | 54.87 | -3.23 |