| 9/1/2012 | Jackson State (7-5) | 9 | at | Mississippi State | 56 | SWAC (1AA) | ||
| 9/8/2012 | Auburn (3-9,0-8) | 10 | at | Mississippi State | 28 | |||
| 9/15/2012 | Mississippi State | 30 | at | Troy (5-7) | 24 | at SBC | ||
| 9/22/2012 | South Alabama (2-11) | 10 | at | Mississippi State | 30 | SBC | ||
| 10/6/2012 | Mississippi State | 27 | at | Kentucky (2-10,0-8) | 14 | |||
| 10/13/2012 | Tennessee (5-7,1-7) | 31 | at | Mississippi State | 41 | |||
| 10/20/2012 | Middle Tenn State (8-4) | 3 | at | Mississippi State | 45 | SBC | ||
| 10/27/2012 | Mississippi State | 7 | at | Alabama (13-1,8-1) | 38 | |||
| 11/3/2012 | Texas A&M (11-2,6-2) | 38 | at | Mississippi State | 13 | |||
| 11/10/2012 | Mississippi State | 17 | at | LSU (10-3,6-2) | 37 | |||
| 11/17/2012 | Arkansas (4-8,2-6) | 14 | at | Mississippi State | 45 | |||
| 11/24/2012 | Mississippi State | 24 | at | Mississippi (7-6,3-5) | 41 | |||
| 1/1/2013 | Mississippi State | 20 | vs | Northwestern (10-3) | 34 | Taxslayer.com Gator Bowl | vs B10 |
| vs Mississippi State | vs Other Opponents | Mississippi State compared to OOs | |
| Record: | 5-8 | 82-68 | |
| Points Scored: | 23.31 | 29.65 | 6.34 |
| Points Allowed: | 29.46 | 25.61 | 3.85 |
| Margin: | -6.15 | 4.04 | 10.19 |
| Total Points: | 52.77 | 55.26 | -2.49 |