| 9/10/2011 | Claremont-Mudd-Scripps Staggs 14 @ Lewis & Clark 36 | |
| 9/17/2011 | Lewis & Clark 48 @ Pomona-Pitzer Sagehens 39 | |
| 9/24/2011 | Lewis & Clark 37 @ Macalester Scots 28 | |
| 10/1/2011 | Lewis & Clark 61 @ Pacific Boxers 35 | † |
| 10/15/2011 | Whitworth Pirates 22 @ Lewis & Clark 30 | † |
| 10/22/2011 | Puget Sound Loggers 28 @ Lewis & Clark 31 | † |
| 10/29/2011 | Lewis & Clark 34 @ Pacific Lutheran Lutes 32 | † |
| 11/5/2011 | Willamette Bearcats 57 @ Lewis & Clark 28 | † |
| 11/12/2011 | Lewis & Clark 14 @ Linfield Wildcats 47 | † |