| 9/1/2011 | Western Illinois Leathernecks 6 @ Sam Houston 20 | |
| 9/17/2011 | Central Arkansas Bears 10 @ Sam Houston 31 | † |
| 9/24/2011 | Sam Houston 48 @ New Mexico Lobos 45 1OT | |
| 10/1/2011 | Texas-San Antonio Roadrunners 7 @ Sam Houston 22 | |
| 10/8/2011 | Stephen F. Austin Lumberjacks 10 vs Sam Houston 45 ( Houston TX ) | † |
| 10/15/2011 | Nicholls State Colonels 7 @ Sam Houston 47 | † |
| 10/22/2011 | Sam Houston 38 @ McNeese State Cowboys 14 | † |
| 10/29/2011 | Lamar Cardinals 0 @ Sam Houston 66 | † |
| 11/5/2011 | Sam Houston 38 @ Southeastern Louisiana Lions 9 | † |
| 11/12/2011 | Northwestern State Demons 17 @ Sam Houston 43 | † |
| 11/19/2011 | Sam Houston 36 @ Texas State Bobcats 14 | |
| 12/3/2011 | Stony Brook Seawolves 27 @ Sam Houston 34 ( FCS Round 2 ) | |
| 12/10/2011 | Montana State Bobcats 13 @ Sam Houston 49 ( FCS Quarterfinals ) | |
| 12/16/2011 | Montana Grizzlies 28 @ Sam Houston 31 ( FCS Seminifnals ) | |
| 1/7/2012 | North Dakota State Bison 17 vs Sam Houston 6 ( FCS Championship - Frisco TX ) |