| 9/3/2011 | UCLA Bruins 34 @ Houston 38 | |
| 9/10/2011 | Houston 48 @ North Texas Eagles 23 | |
| 9/17/2011 | Houston 35 @ Louisiana Tech Bulldogs 34 | |
| 9/24/2011 | Georgia State Panthers 0 @ Houston 56 | |
| 9/29/2011 | Houston 49 @ UTEP Miners 42 | † |
| 10/8/2011 | East Carolina Pirates 3 @ Houston 56 | † |
| 10/22/2011 | Marshall Thundering Herd 28 @ Houston 63 | † |
| 10/27/2011 | Rice Owls 34 @ Houston 73 | † |
| 11/5/2011 | Houston 56 @ UAB Blazers 13 | † |
| 11/10/2011 | Houston 73 @ Tulane Green Wave 17 | † |
| 11/19/2011 | SMU Mustangs 7 @ Houston 37 | † |
| 11/25/2011 | Houston 48 @ Tulsa Golden Hurricane 16 | † |
| 12/3/2011 | Southern Miss Golden Eagles 49 @ Houston 28 ( CUSA ) | † |
| 1/2/2012 | Houston 30 vs Penn State Nittany Lions 14 ( TicketCity Bowl ) |