| 9/3/2011 | Notre Dame OH 23 @ Mercyhurst Lakers 24 1OT | |
| 9/10/2011 | Notre Dame OH 20 @ Walsh Cavaliers 17 | † |
| 9/17/2011 | Notre Dame OH 0 @ Marian IN Knights 38 | |
| 9/24/2011 | Sienna Heights 6 @ Notre Dame OH 30 | |
| 10/1/2011 | Central State Marauders 16 @ Notre Dame OH 34 | † |
| 10/8/2011 | St Joseph's Pumas 14 @ Notre Dame OH 45 | |
| 10/15/2011 | Notre Dame OH 49 @ Ave Maria Gyrenes 3 | |
| 10/22/2011 | Notre Dame OH 16 @ Urbana Blue Knights 49 | |
| 10/29/2011 | Malone Pioneers 31 @ Notre Dame OH 23 | † |
| 11/5/2011 | Kentucky Wesleyan Panthers 38 @ Notre Dame OH 13 | |
| 11/12/2011 | Notre Dame OH 0 @ North Greenville Crusaders 62 | † |