| 9/3/2011 | South Florida Bulls 23 @ Notre Dame 20 |
| 9/10/2011 | Notre Dame 31 @ Michigan Wolverines 35 |
| 9/17/2011 | Michigan State Spartans 13 @ Notre Dame 31 |
| 9/24/2011 | Notre Dame 15 @ Pittsburgh Panthers 12 |
| 10/1/2011 | Notre Dame 38 @ Purdue Boilermakers 10 |
| 10/8/2011 | Air Force Falcons 33 @ Notre Dame 59 |
| 10/22/2011 | Southern California Trojans 31 @ Notre Dame 17 |
| 10/29/2011 | Navy Midshipmen 14 @ Notre Dame 56 |
| 11/5/2011 | Notre Dame 24 @ Wake Forest Demon Deacons 17 |
| 11/12/2011 | Maryland Terrapins 21 vs Notre Dame 45 ( Landover MD ) |
| 11/19/2011 | Boston College Eagles 14 @ Notre Dame 16 |
| 11/26/2011 | Notre Dame 14 @ Stanford Cardinal 28 |
| 12/29/2011 | Florida State Seminoles 18 vs Notre Dame 14 ( Champs Sports Bowl ) |