| 9/4/2010 | Jacksonville | @ | Old Dominion | ||||||
| 9/11/2010 | Old Dominion | @ | Campbell | ||||||
| 9/18/2010 | William & Mary | @ | Old Dominion | ||||||
| 9/25/2010 | Old Dominion | @ | Monmouth NJ | ||||||
| 10/2/2010 | Gardner Webb | @ | Old Dominion | ||||||
| 10/9/2010 | Cal Poly | @ | Old Dominion | ||||||
| 10/23/2010 | Georgia St NAIA | @ | Old Dominion | ||||||
| 10/30/2010 | Old Dominion | @ | Hampton | ||||||
| 11/6/2010 | Savannah St | @ | Old Dominion | 1AAInd | |||||
| 11/13/2010 | VMI | @ | Old Dominion | ||||||
| 11/20/2010 | Old Dominion | @ | North Carolina Central | 1AAInd |