| 9/4/2010 | Purdue | 12 | @ | Notre Dame | 23 | ||
| 9/11/2010 | Michigan | 28 | @ | Notre Dame | 24 | ||
| 9/18/2010 | Notre Dame | 31 | @ | #15 Michigan State | 34 | OT | |
| 9/25/2010 | #4 Stanford | 37 | @ | Notre Dame | 14 | ||
| 10/2/2010 | Notre Dame | 31 | @ | Boston College | 13 | ||
| 10/9/2010 | Pittsburgh | 17 | @ | Notre Dame | 23 | ||
| 10/16/2010 | Western Michigan | 20 | @ | Notre Dame | 44 | ||
| 10/23/2010 | Notre Dame | 17 | vs | Navy | 35 | East Rutherford NJ | |
| 10/30/2010 | Tulsa | 28 | @ | Notre Dame | 27 | ||
| 11/13/2010 | #20 Utah | 3 | @ | Notre Dame | 28 | ||
| 11/20/2010 | Notre Dame | 27 | vs | Army | 3 | Bronx NY | |
| 11/27/2010 | Notre Dame | 20 | @ | Southern California | 16 | ||
| 12/31/2010 | Notre Dame | 33 | vs | Miami-Florida | 17 | El Paso - Sun Bowl |