11 Jan 2011 5:05pm (US Central)
| 0-2 | — | 0 | (1 Common Ops) | 0 | Auburn | 14-0 |
| L 21-58 at | 9/11/2010 | Clemson (5-6) | 9/18/2010 | W 27-24 1 |
|
| 0-2 | — | 0 | (2 Common Ops) | 0 | Boston College | 7-6 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 11/6/2010 | W 23-13 at |
| L 21-58 at | 9/11/2010 | Clemson (5-6) | 10/30/2010 | W 16-10 |
| 0-2 | 7-14 | 2-0 |
|
| 0-1 | — | 0 | (1 Common Ops) | 1 | Clemson | 5-7 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 11/20/2010 | W 30-10 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Duke | 3-9 |
| L 13-53 at | 9/2/2010 | Wake Forest (1-9) | 9/11/2010 | L 48-54 at |
|
| 0-2 | — | 0 | (2 Common Ops) | 0 | Florida State | 10-4 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 9/25/2010 | W 31-0 |
| L 21-58 at | 9/11/2010 | Clemson (5-6) | 11/13/2010 | W 16-13 |
| 0-2 | 7-14 | 2-0 |
|
| 0-2 | — | 0 | (2 Common Ops) | 0 | Georgia Tech | 6-7 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 10/2/2010 | W 24-20 at |
| L 21-58 at | 9/11/2010 | Clemson (4-7) | 10/23/2010 | L 13-27 at |
| 0-2 | 6-15 | 1-1 |
|
| 0-2 | — | 0 | (2 Common Ops) | 0 | Maryland | 9-4 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 10/30/2010 | W 62-14 |
| L 21-58 at | 9/11/2010 | Clemson (4-7) | 10/16/2010 | L 7-31 at |
| 0-2 | 6-15 | 1-1 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Miami-Florida | 7-6 |
| L 21-58 at | 9/11/2010 | Clemson (5-6) | 10/2/2010 | W 30-21 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Navy | 9-4 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 10/9/2010 | W 28-27 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | North Carolina | 8-5 |
| L 21-58 at | 9/11/2010 | Clemson (5-6) | 10/9/2010 | W 21-16 |
|
| 0-2 | — | 0 | (2 Common Ops) | 0 | North Carolina State | 9-4 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 11/13/2010 | W 38-3 |
| L 21-58 at | 9/11/2010 | Clemson (4-7) | 11/6/2010 | L 13-14 at |
| 0-2 | 6-15 | 1-1 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | North Texas | 3-9 |
| L 21-58 at | 9/11/2010 | Clemson (4-7) | 9/4/2010 | L 10-35 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | South Carolina | 9-5 |
| L 21-58 at | 9/11/2010 | Clemson (5-6) | 11/27/2010 | W 29-7 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | South Florida | 8-5 |
| L 21-58 at | 9/11/2010 | Clemson (5-6) | 12/31/2010 | W 31-26 vs |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Stanford | 12-1 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 9/18/2010 | W 68-24 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Vanderbilt | 2-10 |
| L 13-53 at | 9/2/2010 | Wake Forest (1-9) | 11/27/2010 | L 13-34 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Virginia Tech | 11-3 |
| L 13-53 at | 9/2/2010 | Wake Forest (2-8) | 10/16/2010 | W 52-21 |
|
| 0-1 | — | 0 | (1 Common Ops) | 1 | Wake Forest | 2-9 |
| L 21-58 at | 9/11/2010 | Clemson (4-7) | 11/20/2010 | L 10-30 |
|