11 Jan 2011 5:05pm (US Central)
| 1-1 | — | 0 | (1 Common Ops) | 0 | Buffalo | 2-10 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 9/18/2010 | L 10-24 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | East Carolina | 6-7 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 10/30/2010 | L 35-49 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Georgia | 6-7 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 12/31/2010 | L 6-10 vs |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Houston | 5-7 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 11/5/2010 | L 33-40 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Illinois | 7-6 |
| W 41-38 at | 9/11/2010 | Minnesota (2-8) | 11/13/2010 | L 34-38 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Iowa | 8-5 |
| W 41-38 at | 9/11/2010 | Minnesota (2-8) | 11/27/2010 | L 24-27 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Kansas State | 7-6 |
| L 7-38 at | 9/4/2010 | UCF (10-2) | 9/25/2010 | W 17-13 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Marshall | 5-7 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 10/13/2010 | L 14-35 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Memphis | 1-11 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 11/27/2010 | L 17-37 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Michigan State | 11-2 |
| W 41-38 at | 9/11/2010 | Minnesota (3-7) | 11/6/2010 | W 31-8 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Middle Tenn State | 6-7 |
| W 41-38 at | 9/11/2010 | Minnesota (2-8) | 9/2/2010 | L 17-24 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | North Carolina State | 9-4 |
| L 7-38 at | 9/4/2010 | UCF (10-2) | 9/11/2010 | W 28-21 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Northern Illinois | 11-3 |
| W 41-38 at | 9/11/2010 | Minnesota (3-7) | 9/25/2010 | W 34-23 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Northwestern | 7-6 |
| W 41-38 at | 9/11/2010 | Minnesota (3-7) | 10/2/2010 | W 29-28 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Ohio State | 12-1 |
| W 41-38 at | 9/11/2010 | Minnesota (3-7) | 10/30/2010 | W 52-10 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Penn State | 7-6 |
| W 41-38 at | 9/11/2010 | Minnesota (3-7) | 10/23/2010 | W 33-21 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Purdue | 4-8 |
| W 41-38 at | 9/11/2010 | Minnesota (3-7) | 10/16/2010 | W 28-17 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Rice | 4-8 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 10/23/2010 | L 14-41 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | SMU | 7-7 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 12/4/2010 | L 7-17 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Southern California | 8-5 |
| W 41-38 at | 9/11/2010 | Minnesota (3-7) | 9/18/2010 | W 32-21 at |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | Southern Miss | 8-5 |
| L 7-38 at | 9/4/2010 | UCF (10-2) | 11/13/2010 | W 31-21 at |
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| 1-1 | — | 0 | (1 Common Ops) | 0 | Tulane | 4-8 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 11/20/2010 | L 14-61 |
|
| 1-1 | — | 0 | (1 Common Ops) | 0 | UAB | 4-8 |
| L 7-38 at | 9/4/2010 | UCF (9-3) | 10/6/2010 | L 7-42 at |
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| 1-1 | — | 0 | (1 Common Ops) | 0 | Wisconsin | 11-2 |
| W 41-38 at | 9/11/2010 | Minnesota (3-7) | 10/9/2010 | W 41-23 |
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