11 Jan 2011 5:05pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Ball State | 4-8 |
| L 21-31 at | 9/11/2010 | Purdue (2-8) | 9/18/2010 | L 13-24 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Illinois | 7-6 |
| L 21-31 at | 9/11/2010 | Purdue (3-7) | 10/30/2010 | W 44-10 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Indiana | 5-7 |
| L 21-31 at | 9/11/2010 | Purdue (3-7) | 11/27/2010 | W 34-31 1 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Michigan | 7-6 |
| L 21-31 at | 9/11/2010 | Purdue (3-7) | 11/13/2010 | W 27-16 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Michigan State | 11-2 |
| L 21-31 at | 9/11/2010 | Purdue (3-7) | 11/20/2010 | W 35-31 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Minnesota | 3-9 |
| L 21-31 at | 9/11/2010 | Purdue (2-8) | 10/16/2010 | L 17-28 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Northwestern | 7-6 |
| L 21-31 at | 9/11/2010 | Purdue (2-8) | 10/9/2010 | L 17-20 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Notre Dame | 8-5 |
| L 21-31 at | 9/11/2010 | Purdue (3-7) | 9/4/2010 | W 23-12 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Ohio State | 12-1 |
| L 21-31 at | 9/11/2010 | Purdue (3-7) | 10/23/2010 | W 49-0 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Toledo | 8-5 |
| L 21-31 at | 9/11/2010 | Purdue (3-7) | 9/25/2010 | W 31-20 at |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Wisconsin | 11-2 |
| L 21-31 at | 9/11/2010 | Purdue (3-7) | 11/6/2010 | W 34-13 at |
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