11 Jan 2011 5:05pm (US Central)
| 0-2 | — | 0 | (1 Common Ops) | 0 | Baylor | 7-6 |
| L 21-58 at | 11/20/2010 | Texas Tech (6-5) | 10/9/2010 | L 38-45 vs |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Clemson | 6-7 |
| L 20-38 at | 9/4/2010 | Boston College (5-6) | 10/30/2010 | L 10-16 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Colorado | 5-7 |
| L 21-58 at | 11/20/2010 | Texas Tech (6-5) | 10/23/2010 | L 24-27 |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Duke | 3-9 |
| L 20-38 at | 9/4/2010 | Boston College (5-6) | 11/13/2010 | L 16-21 |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Florida State | 10-4 |
| L 20-38 at | 9/4/2010 | Boston College (6-5) | 10/16/2010 | W 24-19 |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Houston | 5-7 |
| L 21-58 at | 11/20/2010 | Texas Tech (6-5) | 11/27/2010 | L 20-35 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Iowa State | 5-7 |
| L 21-58 at | 11/20/2010 | Texas Tech (7-4) | 10/2/2010 | W 52-38 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Kent State | 5-7 |
| L 20-38 at | 9/4/2010 | Boston College (5-6) | 9/11/2010 | L 13-26 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Maryland | 9-4 |
| L 20-38 at | 9/4/2010 | Boston College (6-5) | 10/23/2010 | W 24-21 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Missouri | 10-3 |
| L 21-58 at | 11/20/2010 | Texas Tech (6-5) | 11/6/2010 | L 17-24 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Nevada | 13-1 |
| L 20-38 at | 9/4/2010 | Boston College (6-5) | 1/9/2011 | W 20-13 vs |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | New Mexico | 1-11 |
| L 21-58 at | 11/20/2010 | Texas Tech (6-5) | 9/11/2010 | L 17-52 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | North Carolina State | 9-4 |
| L 20-38 at | 9/4/2010 | Boston College (6-5) | 10/9/2010 | W 44-17 |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Northwestern | 7-6 |
| L 21-58 at | 11/20/2010 | Texas Tech (6-5) | 1/1/2011 | L 38-45 vs |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Notre Dame | 8-5 |
| L 20-38 at | 9/4/2010 | Boston College (6-5) | 10/2/2010 | W 31-13 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Oklahoma | 12-2 |
| L 21-58 at | 11/20/2010 | Texas Tech (7-4) | 11/13/2010 | W 45-7 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Oklahoma State | 11-2 |
| L 21-58 at | 11/20/2010 | Texas Tech (7-4) | 10/16/2010 | W 34-17 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | SMU | 7-7 |
| L 21-58 at | 11/20/2010 | Texas Tech (6-5) | 9/5/2010 | L 27-35 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Syracuse | 8-5 |
| L 20-38 at | 9/4/2010 | Boston College (5-6) | 11/27/2010 | L 7-16 |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Texas | 5-7 |
| L 21-58 at | 11/20/2010 | Texas Tech (7-4) | 9/18/2010 | W 24-14 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Texas A&M | 9-4 |
| L 21-58 at | 11/20/2010 | Texas Tech (7-4) | 10/30/2010 | W 45-27 |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Virginia | 4-8 |
| L 20-38 at | 9/4/2010 | Boston College (5-6) | 11/20/2010 | L 13-17 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Virginia Tech | 11-3 |
| L 20-38 at | 9/4/2010 | Boston College (6-5) | 9/25/2010 | W 19-0 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Wake Forest | 3-9 |
| L 20-38 at | 9/4/2010 | Boston College (5-6) | 11/6/2010 | L 13-23 |
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