11 Jan 2011 5:05pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Memphis | 1-11 |
| L 28-68 at | 9/4/2010 | Houston (3-7) | 10/30/2010 | L 17-56 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Mississippi State | 9-4 |
| L 28-68 at | 9/4/2010 | Houston (4-6) | 10/9/2010 | W 47-24 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Rice | 4-8 |
| L 28-68 at | 9/4/2010 | Houston (4-6) | 10/16/2010 | W 34-31 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | SMU | 7-7 |
| L 28-68 at | 9/4/2010 | Houston (3-7) | 10/23/2010 | L 20-45 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Southern Miss | 8-5 |
| L 28-68 at | 9/4/2010 | Houston (4-6) | 11/20/2010 | W 59-41 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Texas Tech | 8-5 |
| L 28-68 at | 9/4/2010 | Houston (4-6) | 11/27/2010 | W 35-20 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Tulane | 4-8 |
| L 28-68 at | 9/4/2010 | Houston (3-7) | 9/25/2010 | L 23-42 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Tulsa | 10-3 |
| L 28-68 at | 9/4/2010 | Houston (4-6) | 11/13/2010 | W 28-25 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | UCF | 11-3 |
| L 28-68 at | 9/4/2010 | Houston (4-6) | 11/5/2010 | W 40-33 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | UCLA | 4-8 |
| L 28-68 at | 9/4/2010 | Houston (4-6) | 9/18/2010 | W 31-13 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | UTEP | 6-7 |
| L 28-68 at | 9/4/2010 | Houston (3-7) | 9/10/2010 | L 24-54 at |
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