11 Jan 2011 5:05pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Buffalo | 2-10 |
| L 3-34 at | 9/4/2010 | Baylor (5-6) | 9/11/2010 | L 6-34 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Colorado | 5-7 |
| L 3-34 at | 9/4/2010 | Baylor (5-6) | 10/16/2010 | L 25-31 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Illinois | 7-6 |
| L 3-34 at | 9/4/2010 | Baylor (6-5) | 12/29/2010 | W 38-14 vs |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Kansas | 3-9 |
| L 3-34 at | 9/4/2010 | Baylor (5-6) | 10/2/2010 | L 7-55 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Kansas State | 7-6 |
| L 3-34 at | 9/4/2010 | Baylor (5-6) | 10/23/2010 | L 42-47 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Oklahoma | 12-2 |
| L 3-34 at | 9/4/2010 | Baylor (6-5) | 11/20/2010 | W 53-24 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Oklahoma State | 11-2 |
| L 3-34 at | 9/4/2010 | Baylor (6-5) | 11/6/2010 | W 55-28 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Rice | 4-8 |
| L 3-34 at | 9/4/2010 | Baylor (5-6) | 9/25/2010 | L 13-30 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | TCU | 13-0 |
| L 3-34 at | 9/4/2010 | Baylor (6-5) | 9/18/2010 | W 45-10 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Texas | 5-7 |
| L 3-34 at | 9/4/2010 | Baylor (5-6) | 10/30/2010 | L 22-30 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Texas A&M | 9-4 |
| L 3-34 at | 9/4/2010 | Baylor (6-5) | 11/13/2010 | W 42-30 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Texas Tech | 8-5 |
| L 3-34 at | 9/4/2010 | Baylor (6-5) | 10/9/2010 | W 45-38 vs |
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