11 Jan 2011 5:04pm (US Central)
| 0-2 | — | 0 | (1 Common Ops) | 0 | Akron | 1-11 |
| L 14-49 at | 9/11/2010 | Western Michigan (4-6) | 10/23/2010 | L 10-56 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Ball State | 4-8 |
| L 14-49 at | 9/11/2010 | Western Michigan (4-6) | 10/9/2010 | L 16-45 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Bowling Green | 2-10 |
| L 14-49 at | 9/11/2010 | Western Michigan (4-6) | 11/26/2010 | L 7-41 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | BYU | 7-6 |
| L 0-47 at | 9/4/2010 | San Diego State (8-3) | 10/9/2010 | W 24-21 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Central Michigan | 3-9 |
| L 14-49 at | 9/11/2010 | Western Michigan (5-5) | 11/5/2010 | W 26-22 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Colorado State | 3-9 |
| L 0-47 at | 9/4/2010 | San Diego State (7-4) | 11/6/2010 | L 19-24 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Eastern Michigan | 2-10 |
| L 14-49 at | 9/11/2010 | Western Michigan (4-6) | 11/13/2010 | L 30-45 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Idaho | 6-7 |
| L 14-49 at | 9/11/2010 | Western Michigan (5-5) | 10/2/2010 | W 33-13 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Kent State | 5-7 |
| L 14-49 at | 9/11/2010 | Western Michigan (4-6) | 11/20/2010 | L 3-38 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Michigan State | 11-2 |
| L 14-49 at | 9/11/2010 | Western Michigan (5-5) | 9/4/2010 | W 38-14 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Missouri | 10-3 |
| L 0-47 at | 9/4/2010 | San Diego State (8-3) | 9/18/2010 | W 27-24 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Navy | 9-4 |
| L 0-47 at | 9/4/2010 | San Diego State (7-4) | 12/23/2010 | L 14-35 vs |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | New Mexico | 1-11 |
| L 0-47 at | 9/4/2010 | San Diego State (7-4) | 10/23/2010 | L 20-30 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | New Mexico State | 2-10 |
| L 0-47 at | 9/4/2010 | San Diego State (7-4) | 9/11/2010 | L 21-41 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Northern Illinois | 11-3 |
| L 14-49 at | 9/11/2010 | Western Michigan (5-5) | 10/30/2010 | W 28-21 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Notre Dame | 8-5 |
| L 14-49 at | 9/11/2010 | Western Michigan (5-5) | 10/16/2010 | W 44-20 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | TCU | 13-0 |
| L 0-47 at | 9/4/2010 | San Diego State (8-3) | 11/13/2010 | W 40-35 |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Toledo | 8-5 |
| L 14-49 at | 9/11/2010 | Western Michigan (5-5) | 9/18/2010 | W 37-24 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | UNLV | 2-11 |
| L 0-47 at | 9/4/2010 | San Diego State (7-4) | 11/27/2010 | L 14-48 at |
|
| 0-2 | — | 0 | (1 Common Ops) | 0 | Utah | 10-3 |
| L 0-47 at | 9/4/2010 | San Diego State (8-3) | 11/20/2010 | W 38-34 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Utah State | 4-8 |
| L 0-47 at | 9/4/2010 | San Diego State (7-4) | 9/25/2010 | L 7-41 at |
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| 0-2 | — | 0 | (1 Common Ops) | 0 | Wyoming | 3-9 |
| L 0-47 at | 9/4/2010 | San Diego State (7-4) | 10/30/2010 | L 38-48 |
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