11 Jan 2011 5:04pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Cincinnati | 4-8 |
| L 16-38 at | 9/11/2010 | Pittsburgh (6-5) | 12/4/2010 | L 10-28 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Connecticut | 8-5 |
| L 16-38 at | 9/11/2010 | Pittsburgh (7-4) | 11/11/2010 | W 30-28 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Florida Intl | 7-6 |
| L 16-38 at | 9/11/2010 | Pittsburgh (6-5) | 10/2/2010 | L 17-44 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Kentucky | 6-7 |
| L 16-38 at | 9/11/2010 | Pittsburgh (6-5) | 1/8/2011 | L 10-27 vs |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Louisville | 7-6 |
| L 16-38 at | 9/11/2010 | Pittsburgh (6-5) | 10/30/2010 | L 3-21 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Miami-Florida | 7-6 |
| L 16-38 at | 9/11/2010 | Pittsburgh (7-4) | 9/23/2010 | W 31-3 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Notre Dame | 8-5 |
| L 16-38 at | 9/11/2010 | Pittsburgh (7-4) | 10/9/2010 | W 23-17 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Rutgers | 4-8 |
| L 16-38 at | 9/11/2010 | Pittsburgh (6-5) | 10/23/2010 | L 21-41 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | South Florida | 8-5 |
| L 16-38 at | 9/11/2010 | Pittsburgh (6-5) | 11/20/2010 | L 10-17 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Syracuse | 8-5 |
| L 16-38 at | 9/11/2010 | Pittsburgh (6-5) | 10/16/2010 | L 14-45 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Utah | 10-3 |
| L 16-38 at | 9/11/2010 | Pittsburgh (7-4) | 9/2/2010 | W 27-24 1 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | West Virginia | 9-4 |
| L 16-38 at | 9/11/2010 | Pittsburgh (7-4) | 11/26/2010 | W 35-10 at |
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