11 Jan 2011 5:04pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Alabama | 9-3 |
| L 7-45 at | 9/25/2010 | Michigan State (10-1) | 1/1/2011 | W 49-7 vs |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Florida Atlantic | 4-8 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 9/11/2010 | L 17-30 vs |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Illinois | 7-6 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 10/16/2010 | L 6-26 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Iowa | 8-5 |
| L 7-45 at | 9/25/2010 | Michigan State (10-1) | 10/30/2010 | W 37-6 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Michigan | 7-6 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 10/9/2010 | L 17-34 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Minnesota | 3-9 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 11/6/2010 | L 8-31 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Northwestern | 7-6 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 10/23/2010 | L 27-35 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Notre Dame | 8-5 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 9/18/2010 | L 31-34 1 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Penn State | 7-6 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 11/27/2010 | L 22-28 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Purdue | 4-8 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 11/20/2010 | L 31-35 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Western Michigan | 6-6 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 9/4/2010 | L 14-38 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Wisconsin | 11-2 |
| L 7-45 at | 9/25/2010 | Michigan State (9-2) | 10/2/2010 | L 24-34 at |
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