11 Jan 2011 5:04pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Connecticut | 8-5 |
| L 7-40 at | 9/11/2010 | Cincinnati (3-7) | 11/27/2010 | W 38-17 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Fresno State | 8-5 |
| L 7-40 at | 9/11/2010 | Cincinnati (3-7) | 9/4/2010 | W 28-14 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Louisville | 7-6 |
| L 7-40 at | 9/11/2010 | Cincinnati (2-8) | 10/15/2010 | L 27-35 |
|
| 0-1 | — | 0 | (1 Common Ops) | 0 | Miami-Ohio | 10-4 |
| L 7-40 at | 9/11/2010 | Cincinnati (2-8) | 10/9/2010 | L 3-45 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | North Carolina State | 9-4 |
| L 7-40 at | 9/11/2010 | Cincinnati (3-7) | 9/16/2010 | W 30-19 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Oklahoma | 12-2 |
| L 7-40 at | 9/11/2010 | Cincinnati (3-7) | 9/25/2010 | W 31-29 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Pittsburgh | 8-5 |
| L 7-40 at | 9/11/2010 | Cincinnati (3-7) | 12/4/2010 | W 28-10 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Rutgers | 4-8 |
| L 7-40 at | 9/11/2010 | Cincinnati (2-8) | 11/20/2010 | L 38-69 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | South Florida | 8-5 |
| L 7-40 at | 9/11/2010 | Cincinnati (3-7) | 10/22/2010 | W 38-30 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Syracuse | 8-5 |
| L 7-40 at | 9/11/2010 | Cincinnati (3-7) | 10/30/2010 | W 31-7 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | West Virginia | 9-4 |
| L 7-40 at | 9/11/2010 | Cincinnati (3-7) | 11/13/2010 | W 37-10 |
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