11 Jan 2011 5:04pm (US Central)
| 1-0 | — | 0 | (1 Common Ops) | 0 | Ball State | 4-8 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 11/6/2010 | W 37-30 2 |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Buffalo | 2-10 |
| W 38-37 1 at | 9/11/2010 | Akron (0-10) | 11/26/2010 | L 14-22 at |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Indiana | 5-7 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 9/25/2010 | W 35-20 |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Kent State | 5-7 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 10/9/2010 | W 28-17 |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Kentucky | 6-7 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 9/18/2010 | W 47-10 |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Miami-Ohio | 10-4 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 11/17/2010 | W 19-14 at |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Northern Illinois | 11-3 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 10/2/2010 | W 50-14 at |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Ohio | 8-5 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 10/16/2010 | W 38-10 |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Syracuse | 8-5 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 9/4/2010 | W 29-3 at |
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| 1-0 | — | 0 | (1 Common Ops) | 0 | Temple | 8-4 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 10/30/2010 | W 30-0 |
|
| 1-0 | — | 0 | (1 Common Ops) | 0 | Western Michigan | 6-6 |
| W 38-37 1 at | 9/11/2010 | Akron (1-9) | 10/23/2010 | W 56-10 at |
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