11 Jan 2011 5:04pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Arizona | 7-6 |
| L 7-37 at | 9/4/2010 | Iowa (7-4) | 9/18/2010 | W 34-27 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Ball State | 4-8 |
| L 7-37 at | 9/4/2010 | Iowa (6-5) | 9/25/2010 | L 0-45 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Indiana | 5-7 |
| L 7-37 at | 9/4/2010 | Iowa (6-5) | 11/6/2010 | L 13-18 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Iowa State | 5-7 |
| L 7-37 at | 9/4/2010 | Iowa (6-5) | 9/11/2010 | L 7-35 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Michigan | 7-6 |
| L 7-37 at | 9/4/2010 | Iowa (6-5) | 10/16/2010 | L 28-38 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Michigan State | 11-2 |
| L 7-37 at | 9/4/2010 | Iowa (6-5) | 10/30/2010 | L 6-37 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Minnesota | 3-9 |
| L 7-37 at | 9/4/2010 | Iowa (7-4) | 11/27/2010 | W 27-24 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Missouri | 10-3 |
| L 7-37 at | 9/4/2010 | Iowa (6-5) | 12/28/2010 | L 24-27 vs |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Northwestern | 7-6 |
| L 7-37 at | 9/4/2010 | Iowa (7-4) | 11/13/2010 | W 21-17 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Ohio State | 12-1 |
| L 7-37 at | 9/4/2010 | Iowa (7-4) | 11/20/2010 | W 20-17 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Penn State | 7-6 |
| L 7-37 at | 9/4/2010 | Iowa (6-5) | 10/2/2010 | L 3-24 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Wisconsin | 11-2 |
| L 7-37 at | 9/4/2010 | Iowa (7-4) | 10/23/2010 | W 31-30 at |
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