| 9/5/2009 | North Carolina Wesleyan 23 @ Hampden-Sydney 55 | |
| 9/12/2009 | Salisbury 17 @ North Carolina Wesleyan 24 | |
| 9/19/2009 | North Carolina Wesleyan 34 @ Emory & Henry 36 | |
| 10/3/2009 | Ferrum 24 @ North Carolina Wesleyan 34 | † |
| 10/10/2009 | North Carolina Wesleyan 35 @ Greensboro 13 | † |
| 10/17/2009 | North Carolina Wesleyan 35 @ Christopher Newport 7 | † |
| 10/24/2009 | Maryville 17 @ North Carolina Wesleyan 51 | † |
| 10/31/2009 | North Carolina Wesleyan 42 @ Methodist 32 | † |
| 11/7/2009 | Shenandoah 28 @ North Carolina Wesleyan 38 | † |
| 11/14/2009 | North Carolina Wesleyan 49 @ Averett 27 | † |
| 11/21/2009 | North Carolina Wesleyan 23 @ Wesley 55 (D3) |