| 9/5/2009 | Plymouth St 35 @ St Anselm 41 5OT | |
| 9/12/2009 | Mount Ida 16 @ Plymouth St 34 | |
| 9/19/2009 | Coast Guard 17 @ Plymouth St 28 | † |
| 9/26/2009 | Plymouth St 34 @ UMass Dartmouth 0 | † |
| 10/3/2009 | Plymouth St 38 @ Western New England 21 | † |
| 10/10/2009 | Endicott 28 @ Plymouth St 31 | † |
| 10/17/2009 | Nichols 30 @ Plymouth St 48 | † |
| 10/24/2009 | Plymouth St 9 @ Curry 20 | † |
| 10/31/2009 | MIT 7 @ Plymouth St 24 | † |
| 11/7/2009 | Plymouth St 33 @ Salve Regina 7 | † |
| 11/21/2009 | Plymouth St 13 @ Springfield 42 (D3) |