| 9/5/2009 | North Carolina Central 24 @ Hampton 31 | |
| 9/12/2009 | North Carolina Central 10 @ Liberty 35 | |
| 9/19/2009 | Morehead St 13 @ North Carolina Central 10 2OT | |
| 9/26/2009 | North Carolina Central 14 @ Duke 49 | |
| 10/3/2009 | North Carolina Central 17 @ NC A&T 23 1OT | |
| 10/10/2009 | North Carolina Central 21 @ Appalachian St 55 | |
| 10/17/2009 | Central Methodist 7 @ North Carolina Central 52 | |
| 10/31/2009 | Central St 22 @ North Carolina Central 53 | |
| 11/7/2009 | North Carolina Central 28 @ Old Dominion 42 | † |
| 11/14/2009 | North Carolina Central 18 @ Winston-Salem St 10 | |
| 11/21/2009 | Savannah St 14 @ North Carolina Central 35 | † |