| 9/3/2009 | N Dakota St 17 @ Iowa State 34 | |
| 9/12/2009 | Iowa 35 @ Iowa State 3 | |
| 9/19/2009 | Iowa State 34 @ Kent St 14 | |
| 9/26/2009 | Army 10 @ Iowa State 31 | |
| 10/3/2009 | Kansas St 24 vs Iowa State 23 (Kansas City MO) | † |
| 10/10/2009 | Iowa State 36 @ Kansas 41 | † |
| 10/17/2009 | Baylor 10 @ Iowa State 24 | † |
| 10/24/2009 | Iowa State 9 @ Nebraska 7 | † |
| 10/31/2009 | Iowa State 10 @ Texas A&M 35 | † |
| 11/7/2009 | Oklahoma St 34 @ Iowa State 8 | † |
| 11/14/2009 | Colorado 10 @ Iowa State 17 | † |
| 11/21/2009 | Iowa State 24 @ Missouri 34 | † |
| 12/31/2009 | Minnesota 13 vs Iowa State 14 (Insight Bowl) |