| 8/30/2008 Arkansas-Monticello (D2) 21 at Ark Pine Bluff (1AA) 7 |
| 8/30/2008 Birmingham-Southern (D3) 12 at Campbell (1AA) 6 |
| 8/30/2008 Virginia Tech 22 vs East Carolina 27 |
| 8/30/2008 Concordia AL (NAIA) 26 vs Livingstone (D2) 21 |
| 8/30/2008 Mississippi St 14 at Louisiana Tech 22 |
| 8/30/2008 Utah 25 at Michigan 23 |
| 8/30/2008 Bowling Green 27 at Pittsburgh 17 |
| 8/30/2008 Cal Poly (1AA) 29 at San Diego St 27 |
| 8/30/2008 Slippery Rock (D2) 20 at Seton Hill (NAIA) 27 |
| 8/30/2008 Eastern New Mexico (D2) 9 at Southern Nazarene (NAIA) 16 |
| 8/30/2008 Arkansas St 18 at Texas A&M 14 |
| 8/30/2008 Minn St-Moorhead (D3) 29 at Valley City St (NAIA) 30 |
| 8/31/2008 Fayetteville St (D2) 33 at North Carolina Central (1AA) 22 |
| 9/1/2008 Fresno St 24 at Rutgers 7 |
| 9/4/2008 Washburn (D2) 35 at Missouri State (1AA) 27 |
| 9/4/2008 Valparaiso (1AA) 0 at St Francis IL (NAIA) 21 |
| 9/5/2008 Wagner (1AA) 13 at Stonehill (D2) 14 |
| 9/6/2008 Taylor (NAIA) 27 at Anderson (D3) 17 |
| 9/6/2008 New Hampshire (1AA) 28 at Army 10 |
| 9/6/2008 West Virginia 3 at East Carolina 24 |
| 9/6/2008 Ark Pine Bluff (1AA) 0 at Henderson St (D2) 34 |
| 9/6/2008 Martin Luther (NAIA) 40 at Maranatha Baptist (D3) 7 |
| 9/6/2008 Campbell (1AA) 21 at Methodist (D3) 32 |
| 9/6/2008 Maryland 14 at Middle Tenn St 24 |
| 9/6/2008 Wisconsin Lutheran (D3) 7 at Northwestern MN (NAIA) 43 |
| 9/6/2008 St Anselm (D2) 28 at Plymouth St (D3) 36 |
| 9/6/2008 Lincoln PA (D2) 25 at Southern Virginia (NAIA) 55 |
| 9/6/2008 Austin (D3) 14 at SW Assem of God (NAIA) 16 |
| 9/6/2008 Black Hills St (NAIA) 21 at SW Minnesota St (D2) 14 |
| 9/6/2008 Akron 42 at Syracuse 28 |
| 9/6/2008 Davidson (1AA) 9 at UNC Pembroke (D2) 21 |
| 9/6/2008 West Virginia Tech (D2) 19 at Urbana (NAIA) 28 |
| 9/6/2008 BYU 28 at Washington 27 |
| 9/13/2008 Virginia-Wise (NAIA) 42 at Apprentice (D3) 0 |
| 9/13/2008 UNLV 23 at Arizona St 20 OT |
| 9/13/2008 UCLA 0 at BYU 59 |
| 9/13/2008 Franklin (D3) 31 at Butler (1AA) 28 |
| 9/13/2008 Mississippi College (D3) 28 at Cumberland KY (NAIA) 49 |
| 9/13/2008 Shorter (NAIA) 28 at LaGrange (D3) 23 |
| 9/13/2008 Arizona 28 at New Mexico 36 |
| 9/13/2008 UW-Platteville (D3) 17 at St Ambrose (NAIA) 34 |
| 9/13/2008 Stanford 14 at TCU 31 |
| 9/13/2008 Mayville St (NAIA) 9 at Wisconsin Lutheran (D3) 7 |
| 9/18/2008 North Dakota (D2) 38 at Idaho St (1AA) 35 |
| 9/20/2008 UW-La Crosse (D3) 10 at Azusa Pacific (NAIA) 13 |
| 9/20/2008 Howard Payne (D3) 6 at Bacone (NAIA) 13 |
| 9/20/2008 Principia (D3) 0 at Crown (NAIA) 40 |
| 9/20/2008 Seton Hill (NAIA) 34 at Glenville St (D2) 29 |
| 9/20/2008 Ball State 42 at Indiana 20 |
| 9/20/2008 Trinity Int'l (NAIA) 18 at Lincoln MO (D2) 10 |
| 9/20/2008 Blackburn (D3) 14 at Martin Luther (NAIA) 55 |
| 9/20/2008 Rutgers 21 at Navy 23 |
| 9/20/2008 Boise St 37 at Oregon 32 |
| 9/20/2008 Jacksonville (1AA) 21 at UNC Pembroke (D2) 22 |
| 9/20/2008 Iowa State 31 at UNLV 34 OT |
| 9/20/2008 Northwestern MN (NAIA) 41 at UW-River Falls (D3) 34 |
| 9/20/2008 Marian (NAIA) 13 at Valparaiso (1AA) 10 |
| 9/20/2008 West Virginia Tech (D2) 33 at Virginia-Wise (NAIA) 62 |
| 9/27/2008 Adrian (D3) 37 at Lake Erie (D2) 17 |
| 9/27/2008 St Scholastica (D3) 7 at Minnesota-Morris (NAIA) 21 |
| 9/27/2008 Shepherd (D2) 14 at Seton Hill (NAIA) 24 |
| 9/27/2008 Geneva (NAIA) 31 at Thiel (D3) 17 |
| 9/27/2008 Fresno St 36 at UCLA 31 |
| 9/27/2008 Bryant (D2) 24 at Wagner (1AA) 14 |
| 9/27/2008 Navy 24 at Wake Forest 17 |
| 9/27/2008 Campbellsville (NAIA) 57 at West Virginia Tech (D2) 47 |
| 10/2/2008 Oregon St 28 at Utah 31 |
| 10/4/2008 Tuskegee (D2) 34 at Alabama A&M (1AA) 24 |
| 10/4/2008 Northwestern MN (NAIA) 49 at Macalester (D3) 13 |
| 10/4/2008 Crown (NAIA) 51 at St Scholastica (D3) 13 |
| 10/4/2008 Union KY (NAIA) 45 at West Virginia Tech (D2) 27 |
| 10/4/2008 Seton Hill (NAIA) 35 at WV Wesleyan (D2) 32 |
| 10/11/2008 West Virginia Tech (D2) 27 at Belhaven (NAIA) 29 |
| 10/11/2008 Miles (D2) 24 at Concordia AL (NAIA) 29 |
| 10/11/2008 Wesley (D3) 23 at Iona (1AA) 12 |
| 10/11/2008 Toledo 13 at Michigan 10 |
| 10/11/2008 West Virginia St (D2) 28 at Seton Hill (NAIA) 35 |
| 10/18/2008 West Virginia Tech (D2) 19 at Bethel TN (NAIA) 56 |
| 10/18/2008 Robert Morris (1AA) 7 at Bryant (D2) 20 |
| 10/18/2008 Southern Virginia (NAIA) 44 at Gallaudet (D3) 9 |
| 10/18/2008 Panhandle St (D2) 19 at NW Oklahoma St (NAIA) 45 |
| 10/18/2008 Lake Erie (D2) 15 at Salisbury (D3) 39 |
| 10/18/2008 North Greenville (D2) 21 at Shorter (NAIA) 37 |
| 10/18/2008 Northwestern MN (NAIA) 35 at St Scholastica (D3) 14 |
| 10/25/2008 Macalester (D3) 14 at Martin Luther (NAIA) 28 |
| 10/25/2008 Bacone (NAIA) 34 at Panhandle St (D2) 28 |
| 10/25/2008 Concord (D2) 0 at Seton Hill (NAIA) 31 |
| 10/25/2008 Mary Hardin-Baylor (D3) 28 at Southern Oregon (NAIA) 40 |
| 10/25/2008 Geneva (NAIA) 42 at St Vincent (D3) 19 |
| 10/25/2008 Cumberland KY (NAIA) 28 at West Virginia Tech (D2) 19 |
| 10/31/2008 St Scholastica (D3) 42 vs Martin Luther (NAIA) 77 |
| 11/1/2008 Webber Int'l (NAIA) 13 at Apprentice (D3) 10 |
| 11/1/2008 Geneva (NAIA) 38 at Bethany WV (D3) 23 |
| 11/1/2008 Duquesne (1AA) 10 at Bryant (D2) 24 |
| 11/1/2008 Seton Hill (NAIA) 41 at Fairmont St (D2) 38 |
| 11/1/2008 West Virginia Tech (D2) 15 at Faulkner (NAIA) 26 |
| 11/1/2008 Central Michigan 37 at Indiana 34 |
| 11/8/2008 East Texas Baptist (D3) 21 at Azusa Pacific (NAIA) 33 |
| 11/8/2008 Savannah St (1AA) 21 at Edward Waters (NAIA) 26 |
| 11/8/2008 Thomas More (D3) 13 at Geneva (NAIA) 17 |
| 11/8/2008 Wesley (D3) 47 at Lake Erie (D2) 26 |
| 11/8/2008 Martin Luther (NAIA) 49 at St Scholastica (D3) 20 |
| 11/8/2008 Wyoming 13 at Tennessee 7 |
| 11/8/2008 Pikeville (NAIA) 17 at West Virginia Tech (D2) 14 |
| 11/8/2008 Illinois 17 vs Western Michigan 23 |
| 11/15/2008 Seton Hill (NAIA) 14 at American Int'l (D2) 7 |
| 11/15/2008 Westminster PA (D3) 26 at Geneva (NAIA) 29 |
| 11/15/2008 West Virginia Tech (D2) 0 at Georgetown KY (NAIA) 48 |
| 11/15/2008 Bryant (D2) 23 at Iona (1AA) 7 |
| 11/22/2008 North Dakota (D2) 34 at South Dakota (1AA) 31 OT |
| 11/22/2008 Bryant (D2) 23 at St Francis PA (1AA) 0 |