| 8/30/2007 | SE Missouri St | 3 | @ | Cincinnati | 59 | ||||
| 9/8/2007 | Southwest Baptist D2 | 17 | @ | SE Missouri St | 38 | ||||
| 9/15/2007 | Indiana St | 10 | @ | SE Missouri St | 13 | ||||
| 9/22/2007 | SE Missouri St | 21 | @ | Samford | 26 | OVC | |||
| 9/29/2007 | Eastern Illinois | 31 | @ | SE Missouri St | 16 | OVC | |||
| 10/13/2007 | SE Missouri St | 17 | @ | Eastern Kentucky | 44 | OVC | |||
| 10/20/2007 | Murray St | 31 | @ | SE Missouri St | 17 | OVC | |||
| 10/27/2007 | SE Missouri St | 20 | @ | Tennessee-Martin | 55 | OVC | |||
| 11/3/2007 | Austin Peay | 34 | @ | SE Missouri St | 31 | OT | |||
| 11/10/2007 | SE Missouri St | 17 | @ | Missouri State | 55 | ||||
| 11/17/2007 | Jacksonville St | 25 | @ | SE Missouri St | 32 | OVC |