| 9/1/2007 | S Carolina St | 3 | @ | Air Force | 34 | ||||
| 9/8/2007 | S Carolina St | 24 | @ | Bethune-Cookman | 13 | MEAC | |||
| 9/15/2007 | S Carolina St | 3 | @ | South Carolina | 38 | ||||
| 9/22/2007 | Winston-Salem St | 7 | @ | S Carolina St | 20 | MEAC | |||
| 10/6/2007 | S Carolina St | 13 | @ | Norfolk St | 20 | OT | MEAC | ||
| 10/13/2007 | Florida A&M | 14 | @ | S Carolina St | 49 | MEAC | |||
| 10/20/2007 | S Carolina St | 28 | @ | Hampton | 24 | MEAC | |||
| 10/27/2007 | Delaware St | 17 | @ | S Carolina St | 16 | MEAC | |||
| 11/3/2007 | S Carolina St | 59 | @ | Howard | 21 | MEAC | |||
| 11/10/2007 | Morgan St | 21 | @ | S Carolina St | 28 | OT | MEAC | ||
| 11/17/2007 | NC A&T | 7 | vs | S Carolina St | 51 | MEAC | Charleston SC |