| 9/2/2006 | UAB | 17 | @ | #7 Oklahoma | 24 | ||||
| 9/9/2006 | Washington | 20 | @ | #7 Oklahoma | 37 | ||||
| 9/16/2006 | #7 Oklahoma | 33 | @ | Oregon | 34 | ||||
| 9/23/2006 | Middle Tenn St | 0 | @ | #7 Oklahoma | 59 | ||||
| 10/7/2006 | #16 Texas | 28 | vs | #7 Oklahoma | 10 | B12 | Dallas TX | ||
| 10/14/2006 | Iowa State | 9 | @ | #7 Oklahoma | 34 | B12 | |||
| 10/21/2006 | Colorado | 3 | @ | #7 Oklahoma | 24 | B12 | |||
| 10/28/2006 | #7 Oklahoma | 26 | @ | Missouri | 10 | B12 | |||
| 11/4/2006 | #7 Oklahoma | 17 | @ | #21 Texas A&M | 16 | B12 | |||
| 11/11/2006 | Texas Tech | 24 | @ | #7 Oklahoma | 34 | B12 | |||
| 11/18/2006 | #7 Oklahoma | 36 | @ | Baylor | 10 | B12 | |||
| 11/25/2006 | #7 Oklahoma | 27 | @ | Oklahoma St | 21 | B12 | |||
| 12/2/2006 | #22 Nebraska | 7 | @ | #7 Oklahoma | 21 | B12 | Big 12 Championship (Kansas City) | ||
| 1/1/2007 | #9 Boise St | 43 | vs | #7 Oklahoma | 42 | OT | Fiesta |