| 9/2/2006 | Northern Illinois | 12 | @ | #1 Ohio State | 35 | ||||
| 9/9/2006 | #1 Ohio State | 24 | @ | #16 Texas | 7 | ||||
| 9/16/2006 | Cincinnati | 7 | @ | #1 Ohio State | 37 | ||||
| 9/23/2006 | Penn State | 6 | @ | #1 Ohio State | 28 | B10 | |||
| 9/30/2006 | #1 Ohio State | 38 | @ | Iowa | 17 | B10 | |||
| 10/7/2006 | Bowling Green | 7 | @ | #1 Ohio State | 35 | ||||
| 10/14/2006 | #1 Ohio State | 38 | @ | Michigan St | 7 | B10 | |||
| 10/21/2006 | Indiana | 3 | @ | #1 Ohio State | 44 | B10 | |||
| 10/28/2006 | Minnesota | 0 | @ | #1 Ohio State | 44 | B10 | |||
| 11/4/2006 | #1 Ohio State | 17 | @ | Illinois | 10 | B10 | |||
| 11/11/2006 | #1 Ohio State | 54 | @ | Northwestern | 10 | B10 | |||
| 11/18/2006 | #3 Michigan | 39 | @ | #1 Ohio State | 42 | B10 | |||
| 1/8/2007 | #2 Florida | vs | #1 Ohio State | BCS Championship |