| 8/31/2006 | Temple | 3 | @ | Buffalo | 9 | OT | |||
| 9/9/2006 | Buffalo | 40 | @ | Bowling Green | 48 | 3 OT | MAC | ||
| 9/16/2006 | Buffalo | 13 | @ | Northern Illinois | 31 | MAC | |||
| 9/23/2006 | Buffalo | 7 | @ | #10 Auburn | 38 | ||||
| 10/7/2006 | Ball State | 55 | @ | Buffalo | 25 | MAC | |||
| 10/15/2006 | Miami-Ohio | 38 | @ | Buffalo | 31 | MAC | |||
| 10/21/2006 | Buffalo | 7 | @ | Ohio | 42 | MAC | |||
| 10/28/2006 | Buffalo | 0 | @ | #23 Boston College | 41 | ||||
| 11/4/2006 | Kent St | 14 | @ | Buffalo | 41 | MAC | |||
| 11/9/2006 | Buffalo | 16 | @ | Akron | 31 | MAC | |||
| 11/18/2006 | Buffalo | 3 | @ | #5 Wisconsin | 35 | ||||
| 11/24/2006 | Central Michigan | 55 | @ | Buffalo | 28 | MAC |