| 9/12/2020 | UL Lafayette (3-1) | 31 | at | Iowa State | 14 | SBC | ||
| 9/26/2020 | Iowa State | 37 | at | TCU (1-2,1-2) | 34 | |||
| 10/3/2020 | Oklahoma (2-2,1-2) | 30 | at | Iowa State | 37 | |||
| 10/10/2020 | Texas Tech (1-3,0-3) | 15 | at | Iowa State | 31 | |||
| 10/24/2020 | Iowa State | at | Oklahoma State (3-0,2-0) | |||||
| 10/31/2020 | Iowa State | at | Kansas (0-3,0-2) | |||||
| 11/7/2020 | Baylor (1-1,1-1) | at | Iowa State | |||||
| 11/21/2020 | Kansas State (3-1,3-0) | at | Iowa State | |||||
| 11/28/2020 | Iowa State | at | Texas (2-2,1-2) | |||||
| 12/5/2020 | West Virginia (2-1,1-1) | at | Iowa State |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 1-3 | 17-13 | |
| Points Scored: | 27.50 | 33.10 | 5.60 |
| Points Allowed: | 29.75 | 28.30 | 1.45 |
| Margin: | -2.25 | 4.80 | 7.05 |
| Total Points: | 57.25 | 61.40 | -4.15 |