| 9/7/2024 | Wilkes | 43 | at | King's (10-2) | 28 | at MidAC | ||
| 9/13/2024 | Rensselaer (5-5) | 32 | at | Wilkes | 25 | LL | ||
| 9/21/2024 | Wilkes | 17 | at | Brockport State (8-3) | 31 | at E8 | ||
| 9/28/2024 | St John Fisher (3-7) | 21 | at | Wilkes | 28 | E8 | ||
| 10/4/2024 | Wilkes | 54 | at | Juniata (2-8,1-5) | 7 | |||
| 10/12/2024 | Lycoming (4-6,2-4) | 28 | at | Wilkes | 53 | |||
| 10/19/2024 | Wilkes | 69 | at | Keystone (1-9,0-6) | 24 | |||
| 10/26/2024 | Susquehanna (12-2,6-0) | 48 | at | Wilkes | 21 | |||
| 11/9/2024 | Wilkes | 40 | at | Catholic (5-5,3-3) | 15 | |||
| 11/16/2024 | Moravian (7-4,4-2) | 28 | at | Wilkes | 47 | |||
| 11/23/2024 | Wilkes | 21 | vs | Washington and Lee (6-4) | 40 | Salem VA | vs ODC |
| vs Wilkes | vs Other Opponents | Wilkes compared to OOs | |
| Record: | 4-7 | 59-48 | |
| Points Scored: | 27.45 | 28.52 | 1.07 |
| Points Allowed: | 38.00 | 26.29 | 11.71 |
| Margin: | -10.55 | 2.23 | 12.78 |
| Total Points: | 65.45 | 54.81 | 10.64 |