| 8/29/2024 | Walsh | 41 | at | West Liberty | 21 | @ MtnE | ||
| 9/5/2024 | Indiana PA | 19 | at | Ashland | 10 | PSAC | ||
| Northwood | 28 | at | Gannon | 14 | @ PSAC | |||
| Northern Michigan | 13 | at | Kentucky Wesleyan | 33 | GLIAC | |||
| Ohio Dominican | 21 | at | Seton Hill | 14 | @ PSAC | |||
| Wayne State MI | 17 | at | Tiffin | 31 | GLIAC | |||
| 9/7/2024 | Lake Erie | 3 | at | Ferris State | 56 | @ GLIAC | ||
| Indianapolis | 42 | at | Hillsdale | 16 | GLV | |||
| Davenport | 24 | at | Thomas More | 17 | GLIAC | |||
| Findlay | 37 | at | Truman State | 21 | @ GLV | |||
| Wheeling | 14 | at | Walsh | 10 | MtnE | |||
| 9/14/2024 | Ashland | 3 | at | Ferris State | 43 | @ GLIAC | ||
| William Jewell | 23 | at | Kentucky Wesleyan | 16 | GLV | |||
| Post | 27 | at | Lake Erie | 28 | NE10 | |||
| Tiffin | 17 | at | Lenoir-Rhyne | 38 | @ SAC | |||
| Hillsdale | 6 | at | Michigan Tech | 21 | @ GLIAC | |||
| Saginaw Valley State | 7 | at | Northwood | 10 | GLIAC | |||
| Kentucky Christian | 0 | at | Thomas More | 50 | App (NAIA) | |||
| Findlay | 42 | at | Wayne State MI | 30 | @ GLIAC | |||
| Ohio Dominican | 13 | at | Winston-Salem State | 19 | @ MtnE | |||
| 9/21/2024 | Lake Erie | 6 | at | Findlay | 42 | |||
| Ashland | 24 | at | Hillsdale | 21 | ||||
| Thomas More | 6 | at | Ohio Dominican | 0 | ||||
| Northwood | 23 | at | Tiffin | 31 | ||||
| Kentucky Wesleyan | 10 | at | Walsh | 54 | ||||
| 9/28/2024 | Tiffin | 12 | at | Ashland | 21 | |||
| Hillsdale | 21 | at | Findlay | 28 | ||||
| Northwood | 55 | at | Lake Erie | 20 | ||||
| Kentucky Wesleyan | 7 | at | Ohio Dominican | 38 | ||||
| Walsh | 21 | at | Thomas More | 44 | ||||
| 10/5/2024 | Ohio Dominican | 6 | at | Ashland | 26 | |||
| Findlay | 49 | at | Kentucky Wesleyan | 9 | ||||
| Hillsdale | 14 | at | Northwood | 13 | ||||
| Thomas More | 10 | at | Tiffin | 51 | ||||
| Lake Erie | 34 | at | Walsh | 63 | ||||
| 10/12/2024 | Ashland | 41 | at | Findlay | 21 | |||
| Walsh | 36 | at | Hillsdale | 35 | ||||
| Lake Erie | 29 | at | Kentucky Wesleyan | 23 | ||||
| Northwood | 20 | at | Thomas More | 3 | ||||
| Ohio Dominican | 13 | at | Tiffin | 31 | ||||
| 10/19/2024 | Hillsdale | 28 | at | Lake Erie | 10 | |||
| Kentucky Wesleyan | 27 | at | Northwood | 20 | ||||
| Findlay | 26 | at | Ohio Dominican | 10 | ||||
| Ashland | 28 | at | Thomas More | 3 | ||||
| Tiffin | 38 | at | Walsh | 21 | ||||
| 10/26/2024 | Northwood | 7 | at | Ashland | 9 | |||
| Hillsdale | 41 | at | Kentucky Wesleyan | 7 | ||||
| Walsh | 7 | at | Ohio Dominican | 16 | ||||
| Findlay | 34 | at | Thomas More | 17 | ||||
| Lake Erie | 10 | at | Tiffin | 63 | ||||
| 11/2/2024 | Walsh | 17 | at | Findlay | 28 | |||
| Thomas More | 17 | at | Hillsdale | 38 | ||||
| Tiffin | 54 | at | Kentucky Wesleyan | 14 | ||||
| Ashland | 41 | at | Lake Erie | 14 | ||||
| Ohio Dominican | 10 | at | Northwood | 37 | ||||
| 11/9/2024 | Northwood | 17 | at | Findlay | 27 | |||
| Tiffin | 17 | at | Hillsdale | 20 | ||||
| Ohio Dominican | 38 | at | Lake Erie | 21 | ||||
| Kentucky Wesleyan | 12 | at | Thomas More | 47 | ||||
| Ashland | 10 | at | Walsh | 24 | ||||
| 11/16/2024 | Kentucky Wesleyan | 30 | at | Ashland | 44 | |||
| Thomas More | 28 | at | Lake Erie | 25 | ||||
| Walsh | 42 | at | Northwood | 49 | ||||
| Hillsdale | 28 | at | Ohio Dominican | 6 | ||||
| Findlay | 14 | at | Tiffin | 37 | ||||
| 11/23/2024 | Ashland | 40 | at | Charleston WV | 38 | @ MtnE | ||
| 11/30/2024 | Ashland | 33 | at | California PA | 34 | D2 Playoffs Round 2 | @ PSAC | |
| 12/7/2024 | Tiffin | 10 | at | Truman State | 29 | @ GLV |