| 9/2/2023 | Mount Union (11-1) | 45 | at | Defiance | 6 | OAC | ||
| 9/9/2023 | Defiance | 34 | at | Adrian (1-9) | 17 | at MIAA | ||
| 9/16/2023 | Defiance | 35 | at | Kalamazoo (5-5) | 42 | at MIAA | ||
| 9/30/2023 | Defiance | 27 | at | Hanover (7-3,4-3) | 21 | |||
| 10/7/2023 | Mt St Joseph (9-2,7-0) | 62 | at | Defiance | 21 | |||
| 10/14/2023 | Franklin (4-6,4-3) | 35 | at | Defiance | 21 | |||
| 10/21/2023 | Defiance | 36 | at | Anderson (0-10,0-7) | 6 | |||
| 10/28/2023 | Defiance | 51 | at | Manchester (1-9,1-6) | 27 | |||
| 11/4/2023 | Rose-Hulman (7-3,6-1) | 78 | at | Defiance | 54 | |||
| 11/11/2023 | Bluffton (4-6,3-4) | 42 | at | Defiance | 35 |
| vs Defiance | vs Other Opponents | Defiance compared to OOs | |
| Record: | 6-4 | 43-50 | |
| Points Scored: | 37.50 | 31.08 | -6.42 |
| Points Allowed: | 32.00 | 31.01 | 0.99 |
| Margin: | 5.50 | 0.07 | -5.43 |
| Total Points: | 69.50 | 62.09 | 7.41 |