| 9/2/2023 | Texas A&M-Kingsville (7-3) | 30 | at | Colorado Mesa | 10 | LSC | ||
| 9/9/2023 | Colorado Mesa | 28 | at | San Diego (4-7) | 21 | OT | at Pio | |
| 9/16/2023 | Colorado Mesa | 38 | at | South Dakota Tech (5-6,4-5) | 30 | |||
| 9/23/2023 | Black Hills State (6-5,5-4) | 25 | at | Colorado Mesa | 23 | |||
| 9/30/2023 | Colorado Mesa | 7 | at | Western Colorado (10-2,8-1) | 43 | |||
| 10/7/2023 | Colorado Mines (14-1,9-0) | 52 | at | Colorado Mesa | 0 | |||
| 10/14/2023 | Colorado Mesa | 62 | at | Fort Lewis (0-11,0-9) | 14 | |||
| 10/21/2023 | Adams State (3-8,2-7) | 7 | at | Colorado Mesa | 42 | |||
| 10/28/2023 | Colorado Mesa | 20 | at | Colorado State-Pueblo (8-3,7-2) | 59 | |||
| 11/4/2023 | Chadron State (5-6,4-5) | 22 | at | Colorado Mesa | 38 | |||
| 11/11/2023 | Colorado Mesa | 38 | at | New Mexico Highlands (2-9,1-8) | 24 |
| vs Colorado Mesa | vs Other Opponents | Colorado Mesa compared to OOs | |
| Record: | 5-6 | 59-55 | |
| Points Scored: | 29.73 | 28.86 | -0.87 |
| Points Allowed: | 27.82 | 28.28 | -0.46 |
| Margin: | 1.91 | 0.58 | -1.33 |
| Total Points: | 57.55 | 57.14 | 0.41 |