| 9/2/2023 | Central State (5-5) | 24 | vs | Mississippi Valley State | 21 | Chicago IL | SIAC (D2) | |
| 9/16/2023 | Mississippi Valley State | 7 | at | Delta State (10-2) | 35 | at GSC | ||
| 9/23/2023 | Mississippi Valley State | 3 | vs | North Carolina Central (9-3) | 45 | Indianapolis IN | vs MEAC | |
| 9/30/2023 | Florida A&M (12-1,9-0) | 31 | at | Mississippi Valley State | 7 | |||
| 10/7/2023 | Mississippi Valley State | 12 | at | Prairie View (6-6,6-3) | 31 | |||
| 10/14/2023 | Ark Pine Bluff (2-9,1-7) | 17 | at | Mississippi Valley State | 42 | |||
| 10/21/2023 | Jackson State (7-4,6-3) | 21 | at | Mississippi Valley State | 6 | |||
| 10/28/2023 | Mississippi Valley State | 3 | at | Alcorn State (7-4,6-2) | 24 | |||
| 11/2/2023 | Mississippi Valley State | 7 | at | Bethune-Cookman (3-8,2-6) | 20 | |||
| 11/11/2023 | Alabama State (7-4,6-3) | 20 | at | Mississippi Valley State | 3 | |||
| 11/16/2023 | Mississippi Valley State | 21 | at | Alabama A&M (5-6,3-5) | 30 |
| vs Mississippi Valley State | vs Other Opponents | Mississippi Valley State compared to OOs | |
| Record: | 10-1 | 63-51 | |
| Points Scored: | 27.09 | 25.95 | -1.14 |
| Points Allowed: | 12.00 | 25.66 | -13.66 |
| Margin: | 15.09 | 0.29 | -14.80 |
| Total Points: | 39.09 | 51.61 | -12.52 |