| 9/2/2023 | Northern Iowa (6-5) | 9 | at | Iowa State | 30 | MVC (1AA) | ||
| 9/9/2023 | Iowa (10-4) | 20 | at | Iowa State | 13 | B10 | ||
| 9/16/2023 | Iowa State | 7 | at | Ohio (10-3) | 10 | at MAC | ||
| 9/23/2023 | Oklahoma State (10-4,7-3) | 27 | at | Iowa State | 34 | |||
| 9/30/2023 | Iowa State | 20 | at | Oklahoma (10-3,7-2) | 50 | |||
| 10/7/2023 | TCU (5-7,3-6) | 14 | at | Iowa State | 27 | |||
| 10/14/2023 | Iowa State | 30 | at | Cincinnati (3-9,1-8) | 10 | |||
| 10/28/2023 | Iowa State | 30 | at | Baylor (3-9,2-7) | 18 | |||
| 11/4/2023 | Kansas (9-4,5-4) | 28 | at | Iowa State | 21 | |||
| 11/11/2023 | Iowa State | 45 | at | BYU (5-7,2-7) | 13 | |||
| 11/18/2023 | Texas (12-2,9-1) | 26 | at | Iowa State | 16 | |||
| 11/25/2023 | Iowa State | 42 | at | Kansas State (9-4,6-3) | 35 | |||
| 12/29/2023 | Memphis (10-3) | 36 | vs | Iowa State | 26 | Liberty Bowl - Memphis TN | AAC |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 6-7 | 96-57 | |
| Points Scored: | 22.77 | 30.37 | 7.60 |
| Points Allowed: | 26.23 | 24.70 | 1.53 |
| Margin: | -3.46 | 5.67 | 9.13 |
| Total Points: | 49.00 | 55.07 | -6.07 |