| 9/2/2023 | East Carolina | 3 | at | Michigan (15-0) | 30 | at B10 | ||
| 9/9/2023 | Marshall (6-7) | 31 | at | East Carolina | 13 | SBC | ||
| 9/16/2023 | East Carolina | 28 | at | Appalachian State (9-5) | 43 | at SBC | ||
| 9/23/2023 | Gardner-Webb (7-5) | 0 | at | East Carolina | 44 | BigS (1AA) | ||
| 9/30/2023 | East Carolina | 17 | at | Rice (6-7,4-4) | 24 | |||
| 10/12/2023 | SMU (11-3,9-0) | 31 | at | East Carolina | 10 | |||
| 10/21/2023 | UNC-Charlotte (3-9,2-6) | 10 | at | East Carolina | 7 | |||
| 10/28/2023 | East Carolina | 27 | at | Texas-San Antonio (9-4,7-1) | 41 | |||
| 11/4/2023 | Tulane (11-3,8-1) | 13 | at | East Carolina | 10 | |||
| 11/11/2023 | East Carolina | 22 | at | Florida Atlantic (4-8,3-5) | 7 | |||
| 11/18/2023 | East Carolina | 0 | at | Navy (5-7,4-4) | 10 | |||
| 11/25/2023 | Tulsa (4-8,2-6) | 29 | at | East Carolina | 27 |
| vs East Carolina | vs Other Opponents | East Carolina compared to OOs | |
| Record: | 10-2 | 80-64 | |
| Points Scored: | 22.42 | 28.13 | 5.71 |
| Points Allowed: | 17.33 | 24.82 | -7.49 |
| Margin: | 5.09 | 3.31 | -1.78 |
| Total Points: | 39.75 | 52.95 | -13.20 |