| 8/27/2022 | Montana-Western | 10 | at | Carroll MT | 16 | |||
| Montana State-Northern | 3 | at | College of Idaho | 31 | ||||
| Montana Tech | 38 | at | Eastern Oregon | 3 | ||||
| Rocky Mountain | 27 | at | Southern Oregon | 10 | ||||
| 9/3/2022 | Southern Oregon | 56 | at | Montana State-Northern | 6 | |||
| Carroll MT | 10 | at | Montana Tech | 26 | ||||
| Eastern Oregon | 14 | at | Montana-Western | 48 | ||||
| College of Idaho | 21 | at | Rocky Mountain | 18 | ||||
| 9/10/2022 | Dickinson State | 14 | at | Montana-Western | 35 | NSAA | ||
| Eastern Oregon | 7 | at | Whitworth | 33 | @ NWC (D3) | |||
| 9/17/2022 | Carroll MT | 25 | at | Eastern Oregon | 23 | |||
| Montana-Western | 35 | at | Montana State-Northern | 6 | ||||
| Rocky Mountain | 28 | at | Montana Tech | 20 | ||||
| College of Idaho | 42 | at | Southern Oregon | 24 | ||||
| 9/24/2022 | Southern Oregon | 14 | at | Carroll MT | 26 | |||
| Eastern Oregon | 0 | at | College of Idaho | 41 | ||||
| Montana Tech | 33 | at | Montana-Western | 24 | ||||
| Montana State-Northern | 0 | at | Rocky Mountain | 56 | ||||
| 10/1/2022 | College of Idaho | 31 | at | Carroll MT | 20 | |||
| Southern Oregon | 42 | at | Eastern Oregon | 14 | ||||
| Montana State-Northern | 0 | at | Montana Tech | 73 | ||||
| Rocky Mountain | 41 | at | Montana-Western | 26 | ||||
| 10/8/2022 | Montana Tech | 24 | at | College of Idaho | 27 | |||
| Carroll MT | 47 | at | Montana State-Northern | 3 | ||||
| Eastern Oregon | 6 | at | Rocky Mountain | 28 | ||||
| Montana-Western | 14 | at | Southern Oregon | 49 | ||||
| 10/22/2022 | Rocky Mountain | 0 | at | Carroll MT | 24 | |||
| Montana State-Northern | 0 | at | Eastern Oregon | 37 | ||||
| Southern Oregon | 21 | at | Montana Tech | 45 | ||||
| College of Idaho | 35 | at | Montana-Western | 40 | ||||
| 10/29/2022 | Eastern Oregon | 3 | at | Carroll MT | 37 | |||
| Southern Oregon | 24 | at | College of Idaho | 28 | ||||
| Montana State-Northern | 0 | at | Montana-Western | 66 | ||||
| Montana Tech | 20 | at | Rocky Mountain | 17 | ||||
| 11/5/2022 | College of Idaho | 41 | at | Eastern Oregon | 7 | |||
| Rocky Mountain | 9 | at | Montana State-Northern | 0 | ||||
| Montana-Western | 27 | at | Montana Tech | 21 | ||||
| Carroll MT | 24 | at | Southern Oregon | 17 | ||||
| 11/12/2022 | Carroll MT | 21 | at | College of Idaho | 6 | |||
| Montana Tech | 49 | at | Montana State-Northern | 6 | ||||
| Montana-Western | 44 | at | Rocky Mountain | 21 | ||||
| Eastern Oregon | 21 | at | Southern Oregon | 14 | ||||
| 11/19/2022 | Carroll MT | 14 | at | Grand View | 17 | NAIA Championship Round 1 | @ HAAC |