| 8/28/2021 | Fort Lauderdale (0-7) | at | Southeastern FL | 1 | Forfeit | None (Unk?) | ||
| 9/4/2021 | Southeastern FL | 14 | at | Faulkner (7-2,7-2) | 31 | |||
| 9/18/2021 | Thomas More (5-5,5-5) | 14 | at | Southeastern FL | 20 | |||
| 9/25/2021 | Southeastern FL | 14 | at | Cumberlands KY (6-4,6-4) | 63 | |||
| 10/2/2021 | Southeastern FL | 21 | at | Webber International (2-8,2-8) | 0 | |||
| 10/9/2021 | Ave Maria (5-6,5-5) | 34 | at | Southeastern FL | 10 | |||
| 10/16/2021 | Southeastern FL | 20 | at | Keiser (9-3,9-3) | 17 | |||
| 10/23/2021 | Warner U. (3-8,3-7) | 6 | at | Southeastern FL | 34 | |||
| 10/29/2021 | Southeastern FL | 24 | at | St Thomas FL (8-2,7-2) | 21 | |||
| 11/6/2021 | St Andrews (1-9,1-8) | 14 | at | Southeastern FL | 21 | |||
| 11/13/2021 | Florida Memorial (2-9,2-8) | 7 | at | Southeastern FL | 28 |
| vs Southeastern FL | vs Other Opponents | Southeastern FL compared to OOs | |
| Record: | 3-7 | 45-56 | |
| Points Scored: | 20.70 | 26.25 | 5.55 |
| Points Allowed: | 20.60 | 31.62 | -11.02 |
| Margin: | 0.10 | -5.37 | -5.47 |
| Total Points: | 41.30 | 57.87 | -16.57 |