| 9/11/2021 | Lewis & Clark | 10 | at | Claremont-Mudd-Scripps (7-3) | 34 | at SCIAC | ||
| 9/18/2021 | Whittier (0-9) | 14 | at | Lewis & Clark | 66 | SCIAC | ||
| 10/2/2021 | Lewis & Clark | 17 | at | Whitworth (7-3,4-3) | 35 | |||
| 10/9/2021 | Pacific Lutheran (4-5,3-4) | 38 | at | Lewis & Clark | 37 | |||
| 10/16/2021 | Lewis & Clark | 43 | at | Willamette (1-9,1-7) | 41 | |||
| 10/23/2021 | Puget Sound (1-9,1-7) | 29 | at | Lewis & Clark | 46 | |||
| 10/30/2021 | Lewis & Clark | 19 | at | Pacific (6-3,5-2) | 42 | |||
| 11/6/2021 | George Fox (6-3,6-1) | 40 | at | Lewis & Clark | 9 | |||
| 11/13/2021 | Lewis & Clark | 17 | at | Linfield (11-1,7-0) | 51 |
| vs Lewis & Clark | vs Other Opponents | Lewis & Clark compared to OOs | |
| Record: | 6-3 | 37-42 | |
| Points Scored: | 36.00 | 26.14 | -9.86 |
| Points Allowed: | 29.33 | 29.61 | -0.28 |
| Margin: | 6.67 | -3.47 | -10.14 |
| Total Points: | 65.33 | 55.75 | 9.58 |