| 9/2/2021 | Northern State (7-4,7-4) | 34 | at | Minnesota State-Mankato | 40 | OT | ||
| 9/11/2021 | Minnesota State-Mankato | 10 | at | Minnesota-Duluth (9-3,9-2) | 30 | |||
| 9/18/2021 | Bemidji State (10-3,10-2) | 24 | at | Minnesota State-Mankato | 45 | |||
| 9/25/2021 | Minnesota State-Mankato | 68 | at | Minot State (2-9,2-9) | 10 | |||
| 10/2/2021 | Concordia-St Paul (1-10,1-10) | 10 | at | Minnesota State-Mankato | 58 | |||
| 10/9/2021 | Wayne State NE (7-4,7-4) | 35 | at | Minnesota State-Mankato | 24 | |||
| 10/16/2021 | Minnesota State-Mankato | 58 | at | Upper Iowa (1-10,1-10) | 0 | |||
| 10/23/2021 | Augustana SD (9-3,9-3) | 45 | at | Minnesota State-Mankato | 35 | |||
| 10/30/2021 | Sioux Falls (8-3,8-3) | 45 | at | Minnesota State-Mankato | 35 | |||
| 11/6/2021 | Minnesota State-Mankato | 52 | at | Southwest Minnesota State (2-9,2-9) | 0 | |||
| 11/13/2021 | Minnesota State-Mankato | 16 | at | Winona State (7-4,7-4) | 18 |
| vs Minnesota State-Mankato | vs Other Opponents | Minnesota State-Mankato compared to OOs | |
| Record: | 5-6 | 58-56 | |
| Points Scored: | 22.82 | 28.32 | 5.50 |
| Points Allowed: | 40.09 | 28.86 | 11.23 |
| Margin: | -17.27 | -0.54 | 16.73 |
| Total Points: | 62.91 | 57.18 | 5.73 |