| 9/4/2021 | East Central | 0 | at | Harding (11-2,10-1) | 28 | | | |
| 9/11/2021 | Arkansas Tech (4-7,4-7) | 10 | at | East Central | 13 | | | |
| 9/18/2021 | Southern Nazarene (1-10,1-10) | 13 | at | East Central | 40 | | | |
| 9/25/2021 | East Central | 20 | at | Northwestern Oklahoma State (2-9,2-9) | 17 | | | |
| 10/2/2021 | Southern Arkansas (4-7,4-7) | 17 | at | East Central | 38 | | | |
| 10/9/2021 | East Central | 24 | at | Henderson State (9-2,9-2) | 59 | | | |
| 10/16/2021 | Oklahoma Baptist (8-4,7-4) | 47 | at | East Central | 20 | | | |
| 10/23/2021 | East Central | 44 | at | Southwestern Oklahoma State (0-11,0-11) | 34 | | | |
| 10/30/2021 | Ouachita (9-2,9-2) | 43 | at | East Central | 28 | | | |
| 11/6/2021 | East Central | 35 | at | Arkansas-Monticello (5-6,5-6) | 10 | | | |
| 11/13/2021 | East Central | 30 | at | Southeastern Oklahoma State (9-3,8-3) | 28 | | | |